News

May 25, 2018

Together with the Urology departments of the AMC and LUMC, the Center for Proteomics and Metabolomics (CPM) of the LUMC organizes a masterclass on prostate cancer, with attention to innovative technologies, with a plenary presentation given by the Spinoza Chair Awardee of 2018, Prof. K.J. Pienta (Brady Urological Institute, Johns Hopkins Hospital). Other speakers include Guinevere S.M. Kammeijer, Dr. Geertje van de Horst, Fanny Boyaval, Dr. Rudy van Eijsden. The program will start at 14:30, and will include a discussion and networking reception at the end. Attendance is free of charge but you are kindly requested to register here. For more information, see the flyer.

 


Februari 1, 2018

Bram Heijs new group leader for MSI

The Center for Proteomics and Metabolomics, with prof. Manfred Wuhrer at the helm, consists of five groups. From the 1st of February onwards, the Mass Spectrometry Imaging group, previously lead by dr. Liam McDonnell, will have a new leader: Bram Heijs, who will defend his PhD thesis on February 1st, 2018. The title of the thesis is “Lab-on-a-tissue: optimization of on-tissue chemistry for improved mass spectrometry imaging”. Mass spectrometry imaging is a promising, and emerging technology in the field of clinical mass spectrometry. Despite his young age, Bram Heijs has shown great knowledge and professionality which was awarded with the Imabiotech MSI award 2017 for his work on “Histology-guided high resolution mass spectrometry imaging” at the international OurConV conference for mass spectrometry imaging held in Doorn (NL) September 2017.

 


Januari 23, 2018

Mutanome analysis – finding neoepitopes in cancer

This minisimposium, organized by dr. van Veelen (CPM) in collaboration with the Depts. Clinical Oncology and Pathology, will give the participant the opportunity to learn about state-of-the-art strategies for finding neoepitopes for immunotherapy of cancer.
The keynote speaker is Dr. Michal Bassani (Dept. of Oncology University, Ludwig Institute for Cancer Research, Lausanne).
The symposium, held on Tuesday, January 23, 2018 from 14.00 to 17.00, will be followed by drinks, to offer an informal opportunity to make acquaintance with the people behind the science.
Please note that the location is OUTSIDE the LUMC building: Room 1A-20 FSW, building, Leiden University (Wassenaarseweg 52)

 


Januari 16, 2018

The hitchhiker’s guide to data funnels

Within the lecture series “LUMC TOP RESEARCH SEMINARS”, introduced to stimulate competition and to foster collaboration and inspiration/formation of new research ideas, the event of January 16, 2018 will be dedicated to TFA data analytics. Among the speakers, our very own Arzu Tugce Guler, with a presentation titled “the hitchhiker’s guide to data funnels”. The seminar starts at 17:00, in lecture room 3, with an introduction by prof. Jelle Goeman (dept. medical statistics and bioinformatics)

 


Januari, 2018

Gastroenterology publication


The work performed within the IBD-BIOM consortium, of which the CPM was one of the beneficiaries, has resulted in this publication in Gastroenterology (ranked as #1 in gastroenterology with IF=18.1). The large collaborative paper shows that IgG glycosylation is both only biomarker and functional effector in IBD (Inflammatory Bowel Disease). The article, titled “Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases”, is based on the study of 3,441 samples from patients with IBD and matching controls. Sample collection was coordinated by dr. Vito Annese (AOU Careggi University Hospital of Florence) and dr. Dermot McGovern (Cedars Sinai Hospital in Los Angeles). Glycan analysis was performed at Genos in Zagreb and at the CPM (LUMC).
Noortje de Haan (CPM), Mirna Šimurina (University of Zagreb) and Frano Vučković (Genos) share the first authorship of this important contribution.


September, 2017

IMabiotech MSI award to Bram Heijs

During the OurConV Conference for Mass Spectrometry Imaging, held in Doorn (NL) in the last week of September 2017, Bram Heijs received the ImaBiotech MSI award.

This important prize, developed by ImaBiotech four years ago, is an incentive to promote innovation in the field of Mass Spectrometry Imaging.

Bram is working in the Mass Spectrometry Imaging group of the CPM on methods for on-tissue digestion MALDI-MSI and on the application of optimized methods to characterize and differentiate various types of clinical samples. He will defend his thesis, titled “Lab-on-a-tissue: optimization of on-tissue chemistry for improved mass spectrometry imaging”, in early 2018. Since October 2017 he is the new MSI group leader within the Center for Proteomics and Metabolomics.

 


September 29, 2017

Clinical Mass Spectrometry Imaging Symposium

This mini‐symposium on Clinical Mass Spectrometry Imaging will give you the opportunity to learn more about the application of this cutting edge technology in clinical research.

The program will include keynote lectures by outstanding experts in the field, as well as by young promising researchers.

The symposium will be followed by lunch in “Het Paleijhs” (in front of the lecture room), to offer an informal opportunity to make acquaintance
with the people behind the science.

Click here for the flyer, including the full program.

 


June 6, 2017

Former CPM employee is awarded the International Glycoconjugate Organization (IGO) Young Glycoscientist Award 2017

Dr. Yoann Rombouts has been awarded the International Glycoconjugate Organization (IGO) Young Glycoscientist Award 2017, a prestigious price to reward young estabilished glycoscientists who have made pioneering contributions in the field of glycoscience and show great promise for further achievements. The IGO recognized the high value of Dr. Rombouts’ PhD on mycobacterial glycoconjugates (Lille, France) and his postdoctoral work on glycosylation of rheumatoid arthritis-specific autoantibodies (LUMC). During his appointment at the LUMC, dr. Rombouts’ line of research encompassed work carried out both at department of Rheumatology and at the Center for Proteomics and Metabolomics.

Dr. Rombouts will receive the Prize at the 24th International Symposium on Glycoconjugates in Jeju, Korea.


May 11, 2017

Clinical Proteomics and Metabolomics

Thursday, May 11, 2017
17:00, Lecture Room 5

The CPM (Center for Proteomics and Metabolomics) is one of the Technology Focus Areas within the LUMC. On Thursday, May 11, from 17:00 to 19:30 we will have our second CPM research evening, presenting the research focus of the CPM, with particular attention to its collaborations within the LUMC. The title of the event
(held in Lecture Room 5, building 1, LUMC) is: Clinical Proteomics and Metabolomics.

We will highlight selected research topics of the five groups which are active in the CPM (Metabolomics, Proteomics, Glycomics, MS Imaging and Bioinformatics). Particular attention will be dedicated to collaborations within the LUMC, as Prof. Toes (Rheumatology department) will be one of the speakers. The aim is to introduce the CPM, its research, and its facilities to other researchers within and outside the LUMC, and to identify new research opportunities. The symposium will be followed by drinks in Het Paleijhs (in front of the lecture room), to offer an informal opportunity to make acquaintance with the people behind the science.

Click here for the flyer, including the full program.


October 25, 2016

Horizon 2020 funding for advancing personalized medicine

Glysign logo

Lots of research is being done on discovering biomarkers for various diseases to improve diagnostics and therapy, but very few of those biomarkers are actually being used in clinical practice. Specific sugar signatures of diseases are particularly promising for guiding clinicians in their decisions for a personalized healthcare approach. A European consortium, coordinated by the LUMC, is now receiving EU-funding for a successful translation of promising sugar biomarkers into clinical practice by collaborating intensively with healthcare industry.

The European Horizon 2020 program is funding the Marie-Curie European Industrial Doctorates project GlySign. The major goal of the academic-industrial consortium employing six PhD students is to establish clinical assays that are simple, fast and reliable enough to be used in routine clinical analysis. To this end, already known sugar (or glycan) signatures of four different diseases – diabetes, prostate cancer, neonatal alloimmune thrombocytopenia, and rheumatoid arthritis – will be used.

Prof. Manfred Wuhrer, head of the Center for Proteomics and Metabolomics at the LUMC, is the initiator of this project. He has many years experience in the development of analytical methods for the analysis of complex sugars that are attached to proteins in patients’ blood and other samples. These sugar molecules fine-tune the proteins’ functions and can therefore reflect specific changes caused by diseases and other body conditions, such as pregnancy and even a person’s biological age or sex.

The GlySign project will not only train six early-stage researchers in clinical glycan analysis technologies: Likewise, the knowledge and personnel exchange between the clinical, academic and industrial partners will promote the clinical use of glycan markers in disease diagnosis and prognosis. Different training formats, such as regular scientific meetings, internships at the partner institutions as well as business-oriented and scientific workshops, will support these goals. The required steps for the implementation of the developed analytical technologies will be achieved in close collaboration with healthcare industry that are expert in the production of standardized, high-quality assays for their use in routine clinical laboratories. By this, GlySign will contribute to the development of improved, personalized diagnostic and therapeutic approaches for different diseases.


September 15, 2016

Article on antibody glycosylation in rhesus disease treatment wins 2016 RISE award

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The article “Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D” (DOI: 10.1111/trf.12880) has been selected as the best paper published in 2015 in TRANSFUSION’s , and is thus, winner of the RISE Award. This award (Research Innovation in Scientific Excellence) recognizes impeccable study design, innovation, significance, and effective communication in any area of knowledge covered by the journal.
The paper is the result from a collaboration between Sanquin (Dr. G. Vidarsson, Prof. Dr. Ellen van der Schoot) and LUMC/CPM (Prof. Dr. M. Wuhrer). Sample analysis by mass spectrometry was performed by Agnes Hipgrave Ederveen (CPM). The results will contribute to a better understanding of rhesus D hemolytic disease of the newborn, and future research will aid immunoprophylaxis optimization.

The 2016 RISE Award will be presented at the Annual AABB Meeting Opening Ceremony on Saturday, October 22, 2016 in Orlando.


August 30, 2016

Mass spectrometry
in the clinical environment symposium

Thursday, September 22, 2016
17:00, Lecture Room 5, LUMC

The CPM (Center for Proteomics and Metabolomics) is one of the  Technology Focus Areas within the LUMC. On September 22, from 17:00 to 19:00 you will have the opportunity to learn more about the research focus of the CPM, with particular attention to its collaborations within the LUMC. The title of the symposium (held in Lecture Room 5, building 1, LUMC) is: Mass spectrometry in the clinical environment.
It will highlight the research topics of the five different groups which are active in the CPM (Metabolomics, Proteomics, Glycomics, MS imaging and Bioinformatics). The aim is to introduce the CPM, its research, and its facilities to other researchers within and outside the LUMC, and to identify new research opportunities. The symposium will be followed by drinks in Het Paleijhs (in front of the lecture room), to offer an informal opportunity to make acquaintance with the people behind the science.

Click here for the flyer, including the full program.


May 9, 2016

Glycosylation in colorectal cancer: LUMC coordinator of EU-funded consortium

Colorectal cancer (CRC) is the third most common cancer in the world, and the Netherlands are among the top 5 countries with the highest CRC incidence. To advance improvements in early detection and therapy of CRC, the international Marie-Curie European Training Network GlyCoCan (https://glycocan.eu/) will train 13 PhD students in an interdisciplinary environment with substantial industrial involvement. Within the H2020 scheme, the project was awarded € 3.2 million, whereof the LUMC, as coordinating institution, receives almost € 800,000.

CRC screening and glycan research

The treatment of CRC is most successful when detected at an early stage. Therefore, population-based screening of CRC is thought to reduce mortality and healthcare costs. Currently available screening methods, such as the fetal occult blood test, lack sensitivity, specificity or user-friendliness. Glycans (complex sugars) are known to reflect pathological changes, especially in cancer including CRC. However, glycoscience is a young discipline and the structural analysis of glycans is still a major challenge hampering its translation into medical practice. Professor Manfred Wuhrer, head of the Center of Proteomics and Metabolomics at LUMC, is pioneering the field of clinical glycan analysis. He has assembled a consortium of 15 European partners that are all experts in either glycoscience or CRC research.

Multilevel training and research approach

Since CRC incidence is estimated to double within the next 20 years, there is an urgent need for experts to fight this global threat. GlyCoCan as a European Training Network will address this on multiple levels, by focusing on CRC glycobiology and glyco-immunology, as well as at the clinical application of promising diagnostic glycan targets. Uniquely, clinicians, industrial partners and scientists from 8 different European countries will join forces to promote glyco-oncology in the healthcare sector both in Europe and worldwide. By enhancing our understanding of the structure-function relationship of glycans in CRC, GlyCoCan will pave the way for the development of improved diagnostic and prognostic biomarkers and novel therapeutic targets.


April 20-22, 2016

Glycobiology in Health and Disease seminar

April 20-22 the LUMC will host the Glycoscience Japan – The Netherlands Joint Seminar 2016.

glycobiology_in_health_and_diseaseThe theme of this 5-yearly meeting is “Glycobiology in Health and Disease” and more than 35 Japanese and Dutch invited speakers will present their most recent work in this exciting area of research.
Themes include Immunology, Cancer, Development, Genetic Disorders, Chemical Glycobiology and Host-Pathogen Interactions. Many interested in glycobiology specifically have applied for the entire 3-day meeting.

However, in particular for biomedical and medical researchers at LUMC it may be interesting to attend selected presentations and learn more about glycobiology in your research field.

Please feel free to join for individual sessions/presentations of interest to you, without registration.

The full program can be found here.


november 13, 2015

NPP Fall meeting

The 2015 NPP Fall meeting is hosted by the CPM at the LUMC. The program of the meeting can be found the NPP website.