Group leader MS imaging
PhD Bram Heijs
DETAILS
- Research or PhD project:
Method development for MALDI-MSI, and its application in (pre)clinical research. The current work focuses on the multi-OMICS integration of MALDI-MSI data to unravel metabolo-epigenetic interactions in the context of complex tissue architecture.
CURRICULUM VITAE
Group leader Mass Spectrometry Imaging 2018–Present
Center for Proteomics & Metabolomics
Leiden University Medical Center, Leiden, the Netherlands
Post-doctoral scientist 2019–2020
Biomedical Mass Spectrometry
Institute of Hygiene, University Medical Center, Münster, Germany
Supervision: prof. dr. Klaus Dreisewerd, dr. Jens Höhndorf (Bruker Daltonics GmbH)
Education
Ph.D. candidate Center for Proteomics & Metabolomics 2013–2018
Leiden University Medical Center, Leiden, the Netherlands
Supervision: dr. L.A. McDonnell, Prof. dr. J.V.M.G. Bovée
Title: Lab-on-a-tissue: Optimization of On-Tissue Chemistry for Improved
Mass Spectrometry Imaging.
PhD defense: 01-02-2018
MSc Life Science & Technology 2010–2013
University of Leiden, Leiden, the Netherlands
Advisor: Prof. dr. M.H.M. Noteborn
Focusing on biochemistry, proteomics and molecular biology.
BSc Program Life Science & Technology 2005–2011
University of Leiden / Delft University of Technology, Leiden / Delft, the Netherlands
Focusing on biotechnology, cell biology, biochemistry and molecular biology.
Awards
ImaBiotech Mass Spectrometry Imaging award 2017
Publications
-
N-glycomic signature of stage II colorectal cancer and its association with the tumor microenvironment.
Boyaval, F., van Zeijl, R., Dalebout, H., Holst, S., van Pelt, G., Fariña-Sarasqueta, A., Mesker, W., Tollenaar, R., Morreau, H., Wuhrer, M., Heijs, B
Molecular & Cellular Proteomics mcp.RA120.002215. doi: 10.1074/mcp.RA120.002215.
-
MALDI-2 on a trapped ion mobility quadrupole time-of-flight instrument for rapid mass spectrometry imaging and ion mobility separation of complex lipid profiles
Soltwisch, J., Heijs, B., Koch, A., Vens-Cappell, S., Höhndorf, J., Dreisewerd, K
Analytical Chemistry 92 (13), 8697-8703. doi: 10.1021/acs.analchem.0c01747
-
Multimodal mass spectrometry imaging of N-glycans and proteins from the same tissue section. Analytical Chemistry
Heijs, B., Holst, S., Briaire-de Bruijn, I.H., van Pelt, G.W., de Ru, A.H., van Veelen, P.A., Mesker, W.E., Tollenaar, R.A., Drake, R.R., Mehta, A.S., Bovée, J.V.M.G., Wuhrer, M., McDonnell, L.A.
7745-7753. doi:10.1021/acs.analchem.6b01739
Groups:
