At the MS imaging group of the CPM we use matrix-assisted laser desorption/ionization mass spectrometry imaging (MSI) to reveal the molecular architecture of tissues. The MSI technology allows the label-free and spatially correlated analysis of small molecules, metabolites, lipids, (proteolytic) peptides, proteins and their post-translational modifications using the same essential technology. The targeting of the different molecular classes is done through tailoring the sample preparation method. In the CPM MS imaging group we apply MSI to study pathoetiology and progression of various diseases on the molecular level.
