Researcher
Dr. Ieva Palubeckaite
DETAILS
I strive to provide representative cell culture and mass spectrometry solutions for biomedical research, in order to better understand biological function, highlight important pathways of action and identify ideal therapeutic options.
Currently, I’m focused on a large biomolecule analytical project with Janssen Vaccines. I am additionally continuing collaboration projects based on development of advanced cell culture and mass spectrometry imaging techniques.
CURRICULUM VITAE
Ieva graduated her PhD in Dec 2018 titled: ‘Development of MALDI-MSI analysis of novel three-dimensional cell cultures’. Then she moved onto a role in Leiden University Medical Center to establish tailored 3D cell culture and analytical protocols in order to address informational gaps in sarcoma research. Later, funded by an EMBO fellowship, she worked at the Center for Mass Spectrometry and Optical Spectroscopy (CeMOS) in Mannheim where she developed chiral MSI protocols for oncometabolite imaging in rare cancers. During this time she also established a private consultancy for MSI and 3D cell culture applications. Currently, she is a post-doctorate fellow funded by Janssen Vaccines.
- 2022 – Present: Postdoctoral researcher, Leiden University Medical Center, Department Center for Proteomics and Metabolomics, Leiden, The Netherlands.
Development of advanced MALDIbased analytical protocols of biological isolates for Janssen Vaccines. - 2022 Present: Consultant, Ieva Consulting, Leiden, The Netherlands.
Remote consultation or onsite method development: Mass spectrometry imaging, 3D cell culture, drug discovery related in vitro assays (advanced cell culture adaptation). - 2022 Jan 2022 Apr: Development of chiral MSI protocols for oncometabolite imaging in rare cancers.
- 2017 - 2021: Post-doctoral researcher, Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands.
Generation of patientderived sarcoma models, creation of suitable 3D cell culture methods, and the adaptation of appropriate mass spectrometry imaging protocols for their analysis.
2014- 2018: PhD candidate, Sheffield Hallam University, Biomolecular Sciences Research Centre, Sheffield, United Kingdom.
Thesis title: Analysis of three dimensional cultured cells using mass spectrometry imaging
Publications
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Mass spectrometry imaging of endogenous metabolites in response to doxorubicin in a novel 3D osteosarcoma cell culture model
Ieva Palubeckaitė, Lucy Crooks, David P. Smith, Laura M. Cole, Bram Heijs, Christine Le Maitre, Malcolm R. Clench, Neil A. Cross
J Mass Spectrom., 2020, 55:e4461, DOI: 10.1002/jms.4461
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Selection of Effective Therapies Using Three-Dimensional in vitro Modeling of Chondrosarcoma
Palubeckaitė Ieva, Venneker Sanne, Briaire-de Bruijn Inge H., van den Akker Brendy E., Krol Augustinus D., Gelderblom Hans, Bovée Judith V. M. G.
Front Mol Biosci, 2020, 7, 10.3389/fmolb.2020.566291
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The Future in Disease Models for Mass Spectrometry Imaging, Ethical Issues, and the Way Forward.
Day, R.E., Palubeckaite, I.
In: Cole, L. (eds) Imaging Mass Spectrometry . Methods in Molecular Biology, 2017, vol 1618. Humana Press, New York, NY, 10.1007/978-1-4939-7051-3_16
Groups:
Glycomics
