PhD David Falck

Assistant Professor


As a principal investigator, I am responsible for training, mentoring, coaching and supervision of BSc, MSc and PhD students in the broad field of glycomics and glycoproteomics. I lead several independent research lines and contribute to interdisciplinary research projects with local, national and international collaborators. I have financed this through successful research funding acquisition – such as an NWO Veni and an EU ITN –, public-private partnerships and contract research. Further tasks include invited lectures at international conferences, organization of PhD-level courses, reviewing for many respected journals (see and editorial roles for two ‘Frontiers’ journals. I currently serve in the Grant Support Core of the LUMC theme Immunity as well as in the European Glycoscience Community organizing webinars around analytical glycoscience and creating a community of practice around glycoengineering of biopharmaceuticals.

  • Research lines:
  • GlycosylatiOn of Fc receptors
  • Affinity chromatography – mass spectrometry for structure-function characterization of antibody glycoforms
  • Antibody glycosylation in autoimmunity, specifically immunoglobulin A
  • Glycoform-resolved pharmacokinetics studies of therapeutic proteins


I studied chemistry at the WWU Münster, Germany, graduating in 2009 with a thesis at the interface of biochemistry and analytical chemistry. Since these days, I have a passion for liquid chromatography – mass spectrometry (LC-MS) and its applications to biochemical and pharmaceutical questions. Further deepening these skills and knowledge at the VU University Amsterdam, I also obtained significant skills in sample preparation as well as pharmacological assays and became interested in structure-function relationships and DMPK of therapeutic (small) molecules. In 2013, I obtained my PhD with distinction (cum laude; top 4.5% of graduates). In my postdoctoral research at the LUMC, I applied my skills to the highly challenging field of glycoprotein analysis. Bioanalysis, glycobiology, immunology, autoimmunity and therapeutic proteins are fields in which I obtained significant knowledge. In 2018, I became assistant professor and PI, and have or had a co-promotor role for seven PhD candidates.


  • Site-specific glycosylation mapping of Fc gamma receptor IIIb from neutrophils of health donors

    Wojcik I, Sénard T, de Graaf EL, Janssen GMC, de Ru AH, Mohammed Y, van Veelen PA, Vidarsson G, Wuhrer M and Falck D

    Anal Chem, 2020, 92(19), 13172-13181, DOI:

  • Fc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography-mass spectrometry

    Lippold S, Knaupp A, de Ru AH, Tjokrodirijo RTN, van Veelen PA, van Puijenbroek E, de Taeye SW, Reusch D, Vidarsson G, Wuhrer M, Schlothauer T and Falck D

    mAbs, 2021, 13(1), 1982847, DOI:

  • Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

    Falck D, Thomann M, Lechmann M, Koeleman CAM, Malik S, Jany C, Wuhrer M, Reusch D

    mAbs, 2021, 13(1), 1865596, DOI:

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