Researcher
Dr. Constantin Blöchl
DETAILS
My research focus is the development and implementation of novel analytical methods to capture the vast heterogeneity of antibody proteoforms present in the human body. Specifically, we want to assess the characteristics of antibodies that mediate autoimmune diseases such as rheumatoid arthritis. The analytical characterization of autoantibodies is complemented by functional studies to resolve the impact of specific antibody proteoforms and thus provide a better understanding of autoimmune diseases.
CURRICULUM VITAE
Since 2022: Postdoctoral researcher at the Center for Proteomics and Metabolomics at the Leiden University Medical Center.
2018-2022: PhD in Biochemistry at the University of Salzburg under the supervision of Prof. Christian G. Huber.
2012-2017: Bachelor’s and Master’s degree in Molecular Biosciences at the University of Salzburg and the Johannes Kepler University of Linz.
Publications
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Towards middle-up analysis of polyclonal antibodies: subclass-specific N-glycosylation profiling of murine immunoglobulin G (IgG) by means of HPLC-MS
Blöchl, C., Regl, C., Huber, C. G., Winter, P., Weiss, R., & Wohlschlager, T.
Scientific reports, 2020, 10.1: 1-12
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Integrated N-and O-Glycomics of Acute Myeloid Leukemia (AML) Cell Lines
Blöchl, C., Wang, D., Madunić, K., Lageveen-Kammeijer, G. S., Huber, C. G., Wuhrer, M., & Zhang, T.
Cells, 10(11), 3058
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Proteolytic Profiling of Streptococcal Pyrogenic Exotoxin B (SpeB) by Complementary HPLC-MS Approaches
Blöchl, C., Holzner, C., Luciano, M., Bauer, R., Horejs-Hoeck, J., Eckhard, U., Brandstetter H. & Huber, C. G.
International journal of molecular sciences, 23(1), 412.
Groups:
Proteoform Profiling
