Researcher
Dr. Christoph Gstöttner
DETAILS
My research project is about tackling challenges arising in the characterization of new antibody formats as well as of new therapy forms such as gene therapy. Recently I’m working on the development of a multidimensional LC platform for the fast and automated characterization of AAV variants and their capsid proteins. Next to that I focus on the development of CESI-MS methods for the functional characterization of biopharmaceuticals and their affinity receptors.
CURRICULUM VITAE
Dr. Christoph Gstöttner obtained his Ph.D. in 2021 at the Leiden University Medical Center (Netherlands) under the supervision of Prof. M. Wuhrer. His Ph.D. research was focused on the development of electrophoretic but also chromatographic methodologies for the in-depth analysis of biopharmaceuticals such as monoclonal antibodies or newer antibody formats. Before that he worked for 1.5 years in the biopharmaceutical industry, where he also completed his master thesis on the development of an automated platform for the characterization of monoclonal antibodies.
Publications
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Affinity Capillary Electrophoresis-Mass Spectrometry as a Tool to Unravel Proteoform-Specific Antibody-Receptor Interactions
Christoph Gstöttner, Michaela Hook, Tony Christopeit, Alexander Knaupp, Tilman Schlothauer, Dietmar Reusch, Markus Haberger, Manfred Wuhrer, Elena Domínguez-Vega
Analytical Chemistry, 2021, 93, 45, 15133–15141, doi.org/10.1021/acs.analchem.1c03560
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Fast analysis of antibody-derived therapeutics by automated multidimensional liquid chromatography - Mass spectrometry
Sanne Pot, Christoph Gstöttner, Katrin Heinrich, Sina Hoelterhoff, Ingrid Grunert, Michael Leiss, Anja Bathke, Elena Domínguez-Vega
Analytica Chimica Acta, 2021, Volume 1184, 339015, doi.org/10.1016/j.aca.2021.339015
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Structural and Functional Characterization of SARS-CoV-2 RBD Domains Produced in Mammalian Cells
Christoph Gstöttner, Tao Zhang, Anja Resemann, Sophia Ruben, Stuart Pengelley, Detlev Suckau, Tim Welsink, Manfred Wuhrer, Elena Domínguez-Vega
Analytical Chemistry, 2021, 93, 17, 6839–6847, doi.org/10.1021/acs.analchem.1c00893
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