Dr. Christoph Gstöttner

Researcher

c.j.gstoettner@lumc.nl +3171529 6407 orcid

orcid.org/0000-0003-4033-4024

DETAILS

My research project is about tackling challenges arising in the characterization of new antibody formats as well as of new therapy forms such as gene therapy. Recently I’m working on the development of a multidimensional LC platform for the fast and automated characterization of AAV variants and their capsid proteins. Next to that I focus on the development of CESI-MS methods for the functional characterization of biopharmaceuticals and their affinity receptors.

CURRICULUM VITAE

Dr. Christoph Gstöttner obtained his Ph.D. in 2021 at the Leiden University Medical Center (Netherlands) under the supervision of Prof. M. Wuhrer. His Ph.D. research was focused on the development of electrophoretic but also chromatographic methodologies for the in-depth analysis of biopharmaceuticals such as monoclonal antibodies or newer antibody formats. Before that he worked for 1.5 years in the biopharmaceutical industry, where he also completed his master thesis on the development of an automated platform for the characterization of monoclonal antibodies.

Publications

Affinity Capillary Electrophoresis-Mass Spectrometry as a Tool to Unravel Proteoform-Specific Antibody-Receptor Interactions

Christoph Gstöttner, Michaela Hook, Tony Christopeit, Alexander Knaupp, Tilman Schlothauer, Dietmar Reusch, Markus Haberger, Manfred Wuhrer, Elena Domínguez-Vega

Analytical Chemistry, 2021, 93, 45, 15133–15141, doi.org/10.1021/acs.analchem.1c03560

Fast analysis of antibody-derived therapeutics by automated multidimensional liquid chromatography - Mass spectrometry

Sanne Pot, Christoph Gstöttner, Katrin Heinrich, Sina Hoelterhoff, Ingrid Grunert, Michael Leiss, Anja Bathke, Elena Domínguez-Vega

Analytica Chimica Acta, 2021, Volume 1184, 339015, doi.org/10.1016/j.aca.2021.339015

Structural and Functional Characterization of SARS-CoV-2 RBD Domains Produced in Mammalian Cells

Christoph Gstöttner, Tao Zhang, Anja Resemann, Sophia Ruben, Stuart Pengelley, Detlev Suckau, Tim Welsink, Manfred Wuhrer, Elena Domínguez-Vega

Analytical Chemistry, 2021, 93, 17, 6839–6847, doi.org/10.1021/acs.analchem.1c00893

Dr. Christoph Gstöttner

DETAILS

CURRICULUM VITAE

Publications

News

Thesis defense Wei Wang

EFSD/Lilly Europese subsidie (100.000 euro) voor diabetesonderzoek toegekend aan Bruno Guigas (LUCID)

Prof. Ugur Sahin visits CPM

Groups

Proteomics

The proteomics group performs state-of-the art mass spectrometric analyses of peptides/proteins, with an historical focus on immunology, i.e. HLA-peptidomics, cell biology and microbiology.

Glycomics

Glycosylation plays important roles in immunity, development, infectious diseases and cancer.

Metabolomics

Metabolomics is defined as the systemic analysis of the metabolome, which encompasses the totality of the metabolites in a biological system, i.e., the end-points and intermediate products of metabolism

MS Imaging

Mass spectrometry imaging (MSI) is a technology that simultaneously provides the spatial distribution of hundreds of biomolecules directly from tissue.

Bioinformatics

The Bioinformatics group uses computational tools to bring together data from different domains in order to better understand human disease.

Tissue Glycomics

The Tissue Glycomics group is dedicated to study glycosylation in human tissues in health and disease.

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