Scientist
Dr. Bart Claushuis
DETAILS
I studied Biology at Leiden University with a specialization in molecular genetics and biotechnology and graduated in 2020. After obtaining my master’s degree, I started my PhD at the Center for Proteomics and Metabolomics at the LUMC. During these four years, I studied the specificity, structure, and function of a unique group of bacterial proteases called Pro-Pro endopeptidases. I made use of various mass spectrometry techniques including synthetic combinatorial peptide libraries, TAILS N-terminomics and overall comparative proteomics.
Publications
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Non-prime- and prime-side profiling of Pro-Pro endopeptidase specificity using synthetic combinatorial peptide libraries and mass spectrometry
Bart Claushuis, Robert A. Cordfunke, Arnoud H. de Ru, Jordy van Angeren, Ulrich Baumann, Peter A. van Veelen, Manfred Wuhrer, Jeroen Corver, Jan W. Drijfhout, Paul J. Hensbergen
DOT: The Febs Journal, 2024, 291(17), 3820-3838, DOI: https://doi.org/10.1111/febs.17160
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Revised Model for the Type A Glycan Biosynthetic Pathway in Clostridioides difficile Strain 630Δerm Based on Quantitative Proteomics of cd0241–cd0244 Mutant Strains
Bart Claushuis, Arnoud H. de Ru, Sarah A. Rotman, Peter A. van Veelen, Lisa F. Dawson, Brendan W. Wren, Jeroen Corver, Wiep Klaas Smits, Paul J. Hensbergen
DOT: ACS Infect. Dis., 2023, 9(12), 2665-2674, DOI: https://doi.org/10.1021/acsinfecdis.3c00485
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Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597
Bart Claushuis, Arnoud H. de Ru, Peter A. van Veelen, Paul J. Hensbergen and Jeroen Corver
DOT: Access Microbiol., 2024, 6(10), DOI: https://doi.org/10.1099/acmi.0.000855.v3
