Project awarded by LET'S BEAT NF

June 11, 2026

The project will investigate novel molecular markers using mass spectrometry imaging to more accurately define tumor boundaries during malignant peripheral nerve sheath tumor (MPNST) surgery. These markers will subsequently be used to develop innovative in vivo imaging probes, with the goal of improving surgical precision and patient outcomes. The work will be carried out by Simon Miedema and Laura de Bruyn Wölfel, in collaboration with Dr. Nina Ogrinc (CPM), Justus Groen, MD (Neurosurgery), and Prof. Judith Bovée (Pathology).

Groups

Proteomics

The proteomics group performs state-of-the art mass spectrometric analyses of peptides/proteins, with an historical focus on immunology, i.e. HLA-peptidomics, cell biology and microbiology.
Glycomics

Glycosylation plays important roles in immunity, development, infectious diseases and cancer.
Metabolomics

Metabolomics is defined as the systemic analysis of the metabolome, which encompasses the totality of the metabolites in a biological system, i.e., the end-points and intermediate products of metabolism
MS Imaging

Mass spectrometry imaging (MSI) is a technology that simultaneously provides the spatial distribution of hundreds of biomolecules directly from tissue.
Bioinformatics

The Bioinformatics group uses computational tools to bring together data from different domains in order to better understand human disease.
Tissue Glycomics

The Tissue Glycomics group is dedicated to study glycosylation in human tissues in health and disease.
Proteoform Profiling

Proteoforms are very diverse in structure and function. The Proteoform Profiling group focuses on developing and applying MS-based techniques to unravel the structure and function of proteoforms.