Analyzing cell-type-specific dynamics of metabolism in kidney repair

In a close collaboration between the lab of prof. Rabelink and researchers at the Center for Proteomics & Metabolomics a novel platform to visualize and monitor dynamic metabolic changes in the context of tissue morphology was published in Nature Metabolism.

We show, using MALDI-MS imaging at sub-cellular resolution, that in post-ischemic regenerated kidney tubular epithelium there is a persistent reduction in TCA derived biosynthesis. This may render the kidney susceptible to future kidney injury.

This method may be of general relevance to identify cell-type-specific metabolic targets in tissue, including tumors.

Read the full publication, and an editorial dedicated to the manuscript following the links below:

Full manuscript:

https://www.nature.com/articles/s42255-022-00615-8

Nature Metabolism News & Views:

https://www.nature.com/articles/s42255-022-00621-w

Analyzing cell-type-specific dynamics of metabolism in kidney repair

Groups

Proteomics

The proteomics group performs state-of-the art mass spectrometric analyses of peptides/proteins, with an historical focus on immunology, i.e. HLA-peptidomics, cell biology and microbiology.

Glycomics

Glycosylation plays important roles in immunity, development, infectious diseases and cancer.

Metabolomics

Metabolomics is defined as the systemic analysis of the metabolome, which encompasses the totality of the metabolites in a biological system, i.e., the end-points and intermediate products of metabolism

MS Imaging

Mass spectrometry imaging (MSI) is a technology that simultaneously provides the spatial distribution of hundreds of biomolecules directly from tissue.

Bioinformatics

The Bioinformatics group uses computational tools to bring together data from different domains in order to better understand human disease.

Tissue Glycomics

The Tissue Glycomics group is dedicated to study glycosylation in human tissues in health and disease.

Collaborate with us