In a close collaboration between the lab of prof. Rabelink and researchers at the Center for Proteomics & Metabolomics a novel platform to visualize and monitor dynamic metabolic changes in the context of tissue morphology was published in Nature Metabolism.
We show, using MALDI-MS imaging at sub-cellular resolution, that in post-ischemic regenerated kidney tubular epithelium there is a persistent reduction in TCA derived biosynthesis. This may render the kidney susceptible to future kidney injury.
This method may be of general relevance to identify cell-type-specific metabolic targets in tissue, including tumors.
Read the full publication, and an editorial dedicated to the manuscript following the links below:
Nature Metabolism News & Views: